CRC PRESS Boca Raton London New York Washington, D.C. HANDBOOK OF Pharmaceutical Manufacturing Formulations Sterile Products Sarfaraz K. Take the case of paclitaxel, which belongs to a group of compounds known as taxanes, produced by plants belonging to the yew family. Taxanes are widely used as chemotherapy agents, as they inhibit the process of cell division in tumours. In an alternative to the “taxane in solution” formulation, paclitaxel is bound to albumin nanoparticles 6. As the most abundant plasma protein in human blood, albumin is a good choice for the role of ‘carrier excipient’. A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death. Rowe et al., eds. Handbook of Pharmaceutical Excipients, 7th edn. London: Pharmaceutical Press, 2012. 14 Safety Mannitol is a naturally occurring sugar alcohol found in animals and plants; it is present in small quantities in almost all vegetables.
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Neil Shubin describes how he taught a human anatomy course at the University of Chicago, though his degree was in paleontology and his specialty was fish. Yet Shubin’s knowledge of other animals gave him the opportunity to explain complex human anatomy in.
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